Every day, I scan the news for breakthroughs in health / fitness / obesity / etc.

And just about every day, I run into some “expert” who informs the rest of us that permanent weight loss is as simple as “eat less and move more”.

Today’s post is for that “genius”.

eat less move more


In today’s study, researchers looked at the role of gut hormones and the hypothalamus in appetite regulation and obesity.

And I don’t know about you, but when I look at the diagram below and I try to figure out the complicated relationships between the following hormones, neurons, peptides, receptors and neural pathways, I start to believe that appetite control (and in extension – obesity) may be a bit more complicated than “eat less and move more”

gut hormones and appetite control


How about you?

Can you see why pharmaceutical companies have never been able to find a successful weight loss drug?

There are so many different factors at play, it’s almost impossible to pin down that one magic bullet solution.

gut hormones and their effect on food intake and body weight


For example, a few years back they thought that if they could increase your levels of leptin, your appetite would disappear and obesity would be a thing of the past.

Unfortunately, they soon found out that a large percentage of overweight people already had high levels of circulating leptin. Unfortunately, like a type 2 diabetic with high levels of insulin, all of the leptin in the world isn’t going to work properly if the leptin (hormone) receptors won’t allow the leptin to do it’s work.

See, I told you it was complicated.

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