New Diet Drug offers an Alternative to Obesity Surgery

Tesofensine, a new diet drug being developed by the Danish drug company, NeuroSearch, had it’s coming out party at this years European Congress on Obesity.

Recent tests claimed that, with no changes to diet or lifestyle, the average test subject experienced an 11.2% average reduction in weight. In absolute terms, the average test subject lost 11.3 kg / 24.9 lbs. This weight loss took place over the course of a 24 week treatment with 0.5 mg Tesofensine tablets.

More data here.

TIPO-1 results
Placebo
Tesofensine
0.25 mg
Tesofensine
0.5 mg
Tesofensine
1.0 mg
ITT* population
52
52
50
49
Mean weight
at base line (kg)
103.2
101.7
100.1
101.3
Average relative
weight loss
2.0%
6.5%**
11.2%**
12.6%**
Average absolute
weight loss (kg)
2.2
6.7**
11.3**
12.8**

25 lbs over 6 months with no additional exercise or dietary restriction.

Sounds pretty great.

In another test, Tesofensine produced 2.2 kg/4.85 lbs of weight loss in just 2 weeks. Once again, this test required that no dietary or lifestyle changes be made by the participants.

Tesofensine
Placebo
Population (ITT)
n = 16
n = 16
Baseline average BMI
30.7
31.1
Baseline average weight (kg)
102.6
102.6
Total body weight loss (kg)
2.2
0.4
Maximum weight loss (kg)
4.7
1.5

Professor Arne Astrup, president of the International Association for the Study of Obesity said that “if doctors were to encourage users to lose weight before taking the tablets and to eat sensibly and exercise while taking them they could double their weight loss”.

“You could easily come up to 20 per cent weight loss which could offer an alternative to the surgical treatment of obesity which has become the only real cure or effective treatment that can provide a weight loss of that size”.

While I don’t agree with Dr. Astrup’s assertion that bariatric surgery is the only real cure or effective treatment for obesity, I am encouraged by the efficacy of this drug.

The Down Side

Not to be pessimistic, but how many times in the past have drug manufacturers claimed to have formulated the ultimate fat burning pill? Does anyone remember fen-Phen?

Right now, we know that there have been some promising tests. We also know that the drug has the following side effects: mild nausea, diarrhea, constipation, insomnia, mood changes, and, perhaps most importantly, increased heart rate.

My Conclusion

Unless you have a very serious medical condition that requires you to lose weight as soon as possible, I would not recommend being an ‘early adopter’ of any diet drug. NeuroSearch will be running further tests to look at increasing the efficacy and minimizing the side effects.

In the mean time, improving your physical fitness and your food intake is still the best way to go.

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3 thoughts on “New Diet Drug offers an Alternative to Obesity Surgery

  1. This year I am adding some peppers and more herbs.
    My thumb still isn’t very green. I forced myself to do some prep work last weekend. Not much fun.

    Oh well, reap what you sew and all that

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